Constitutive expression of cyclo-oxygenase 2 transgene in hepatocytes protects against liver injury
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چکیده
منابع مشابه
Constitutive expression of cyclo-oxygenase 2 transgene in hepatocytes protects against liver injury.
The effect of COX (cyclo-oxygenase)-2-dependent PGs (prostaglandins) in acute liver injury has been investigated in transgenic mice that express human COX-2 in hepatocytes. We have used three well-established models of liver injury: in LPS (lipopolysaccharide) injury in D-GalN (D-galactosamine)-preconditioned mice; in the hepatitis induced by ConA (concanavalin A); and in the proliferation of h...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 2008
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj20081224